Grey's Anatomy STUNNER: Who's Dead Now?!?

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Another catastrophe has struck Grey's Anatomy.

Another core cast member has said goodbye.

But this one may McHurt for a McWhile: Derek Shepherd is dead.

With Patrick Dempsey having made no secret over the past couple months that he was interested in moving on from the series, his beloved Dr. Derek Shepherd was blindsided by a semi on Grey's Anatomy Season 11 Episode 21

Meredith is now a widow and Dempsey's 11-year run on the wildly popular ABC drama has come to an end.

"Derek Shepherd is and will always be an incredibly important character - for Meredith, for me and for the fans. I absolutely never imagined saying goodbye to our McDreamy, said creator Shonda Rhimes via statement.

"Patrick Dempsey’s performance shaped Derek in a way that I know we both hope became a meaningful example - happy, sad, romantic, painful and always true - of what young women should demand from modern love. His loss will be felt by all.

"Now, Meredith and the entire Grey’s Anatomy family are about to enter uncharted territory as we head into this new chapter of her life. The possibilities for what may come are endless. As Ellis Grey would say: the carousel never stops turning."

The series, of course, has lost a slew of original cast members over the years; from T.R. Knight to Katherine Heigl; Isaiah Washington to Sandra Oh.

But this is McDreamy. This one is really gonna leave a mark.

Said ABC in a statement of its own:

After 11 seasons on Grey’s Anatomy, Patrick Dempsey is moving on to pursue other interests. Dr. Derek Shepherd is an iconic character and we’ve been proud to be the home of ‘McDreamy’ and the ‘Mer/Der’ love story.

The devotion of Grey’s fans throughout the years has been a testament to the creative mind of Shonda Rhimes and Dempsey’s talent. ‘McDreamy’ will be greatly missed and we wish Patrick the very best in his future endeavors.

So... is it finally time for the network to cancel Grey's Anatomy? React now!

NOTE: A special two-hour installment will air on Thursday. Grey's Anatomy Season 11 Episode 22 will be titled "She's Leaving Here."

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