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Carol Ann Susi, the actress who played Mrs. Wolowitz (or at least her memorable voice) on the CBS sitcom The Big Bang Theory, has sadly passed away.

She died Tuesday after a brief battle with cancer.

The longtime TV veteran was 62 years old.

If you watch The Big Bang Theory, you know that viewers never saw her face, but she nonetheless became a larger than life and unmistakable presence.

That voice could carry her a long way.

Just hearing her say “Howard!” was never not entertaining as she let always let the younger Wolowitz (Simon Helberg) know who was really in charge.

Susi’s co-stars and colleagues were saddened by this sudden loss. Said Warner Bros. and The Big Bang Theory producers in a statement Tuesday:

“The Big Bang Theory family has lost a beloved member today with the passing of Carol Ann Susi.”

“Unseen by viewers, the Mrs. Wolowitz character became a bit of a mystery throughout the show’s eight seasons.”

“What was not a mystery, however, was Carol Ann’s immense talent and comedic timing, which were on display during each unforgettable appearance.”

“In addition to her talent, Carol Ann was a constant source of joy and kindness to all,” the statement continued.

“Our thoughts and deepest condolences are with her family during this time, and we will miss her greatly.”

“My heart is broken,” her The Big Bang Theory co-star Kunal Nayyar Tweeted late Tuesday night. “I will miss your smile. Your spirit is forever with us.”

It’s not clear if or how her passing will be written into TBBT.

Seinfeld fans may also remember Susi as the daughter of an unemployment officer who ended up going out on a horrible date with George at one point.

Her other credits through decades of TV work include Cheers, Doogie Howser, M.D., Grey’s Anatomy, Married … with Children and That ’70s Show.