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Prince Harry may have received enthusiastic blessings from his future in-laws in regard to his impending marriage to Meghan Markle.

But the Royal Slab of Red Hot Meat hasn’t exactly received the same warm response from another relative of his beloved fiancee.

Quite the opposite, in fact.

Arm in Arm Together
Photo via Getty

On Wednesday night, Markle’s half-sister, Samantha Grant, actually clapped back pretty hard against Harry and a recent disparaging remark she felt he made against her and her loved ones.

Allow us to explain…

During a special edition of Radio 4’s Today program this week, Harry talked openly about his first holiday season as an engagement individual.

Did Markle enjoy the time she spent with Kate Middleton, Prince William and their kids for Christmas?

What about attending church along with these same members of The Royal Family

"We had an amazing time,” Harry said in response, adding:

“We had great fun staying with my brother and sister-in-law and running round with the kids. Christmas was fantastic.”

Simple enough, right? Totally harmless and not worthy of any kind of rebuke, right?

Not quite.

Off to Church
Photo via Getty

Continuing on about Markle, Harry noted:

“She’s done an absolutely amazing job, she’s getting in there and it’s the family that I suppose she’s never had.”

There it is. The family she’s never had.

Markle, of course, has a family.

She’s actually received some unfortunate hate mail because she’s of mixed descent (her father is white and her mother is black) and, by all accounts, she is very close to her parents.

She is NOT close, however, to her half-sister.

And it’s this half-sister who took exception to Harry’s remark.

“She has a large family. She always did," Grant wrote on Twitter last night, adding:

"Our dad is amazing and completely self sacrificing. We made it so that she had two houses. How fun it was!”

Hey, Harry!

Grant, it is worth noting, has basically no relationship with Markle.

Insiders have said they were raised separately (they are 17 years apart in age) and Grant has taken a few shots at Markle ever since the actress became an international celebrity.

Back in April, for example, she directly said Markle only pretends to be a humanitarian in order to make positive headlines.

There’s also been talk that Grant will soon release a tell-all that slams her siblings, even Tweeting about the memoir last night as follows:

"Excited for my book coming out and wait until you see what our home life was like!"

Prince Harry and Meghan Markle Engagement Pic
Photo via Kensington Palace

Then again, in November, Grant seemed pretty psyched about the couple when asked about them on Good Morning Britain.

“When I watch her with him it’s very real and normal,” she said at the time, expounding:

“You know, we only get that once in a lifetime if we’re lucky. It’s not about royalty so much as it is about love. And that’s wonderful for them.”

So perhaps Grant isn’t completely evil after all.

We can understand why she got a little offended at Harry’s "family" dig, even if he meant to harm by it at all.

This is a situation worth keeping your eye on, however.

The last thing the Royals want is some ugly family feud clouding the excitement over May’s big wedding.