David Letterman is taking his Top 10 Lists, his Stupid Human Tricks, his Stupid Pet Tricks and his unique sense of humor and packing it all up.
The comedian is set to retire as host of The Late Show.
In honor of this sentimental occasion, we've already run down 14 of the greatest guests in Letterman history - and now we're here with 37 of the most unforgettable moments in Letterman history.
They run an impressive gamut, from the host chatting with Charlie Sheen about cocaine to issuing a heartfelt statement about a school shooting.
As evidenced by the emotional tributes being paid his way, there will never be another David Letterman.
These videos help explain why.