Ellen Pompeo on Grey's Anatomy Set: Blue is the New Black!

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Over the years, Grey's Anatomy has featured a main character being run over by a bus.

Also: a giant storm, a hospital shooting and a plane crash, among many other large-scale tragedies.

In other words: this long-running ABC drama isn't known for its humor.

But Ellen Pompeo - who may quit acting when the show's run is complete - is perhaps seeking to change that impression, at least based on the following hilarious set photo the actress posted to her WhoSay account.

Explosion on Grey's Anatomy

"Blue is the new black #8daystillgreys #greysanatomy," Pompeo Tweeted in anticipation of the Grey's Anatomy Season 11 opener, which airs on Thursday, September 25 at 8/7c.

Fellow Shonda Rhimes star Kerry Washington retweeted the photo and added as her own caption:

"UH. MAY. ZING. #TGIT," a reference to the term Thank Good It's Thursday, which ABC is hoping to get trending in relation to the weekly block of Grey's Anatomy at 8 p.m., Scandal at 9 p.m. and How to Get Away With Murder (starring Viola Davis) at 10 p.m.

Grey’s Anatomy fans, meanwhile, should take note: flashbacks are on the way!

"We are doing a lot of flashback stuff. Very challenging...A lot of people say how can you stay on a show 11 years. After 11 seasons you have to stay so alive and present. You can't disappoint the audience. You have to bring it," Pompeo recently said during a panel discussion in Washington.

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