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You do not want to cross Bethenny Frankel on Twitter.

Already dealing with an ugly divorce and custody battle, the former Real Housewife went off on a hater yesterday, responding to some serious vitriol with a bit of her own.

“cupcake decorating w bryn at dc cupcakes & now girls’ lunch,” Frankel Tweeted harmlessly. “It’s crazy to be able to spend a real girls’ day w the peanut. #fliesby”

In response, some moron fired back:

 

“who gives a flying f–k! How soon after eating the cupcake do you purge? U look like an emaciated HIV patient.”

And that’s when this businesswoman couldn’t take it anymore.

Acknowledging that the producers of her talk show – which goes nationwide in September – might not like this, Frankel, in the midst of a split from Jason Hoppy, wrote back:

“go F yourself’ with your rude comments.hatersnotwelcome @peacewithmeself.”

Seriously. Can anyone blame her?