Standup comedian Melissa Rauch was little known in the acting world prior to becoming Bernadette and marrying Simon Helberg's Howard on TBBT.
Sara Gilbert, aka "DARLEEEEEEENE" on Roseanne, joined TBBT for only 8 episodes. During those episodes, she played the love interest of Johnny Galecki's Leonard, making this the second time the two have been romantically involved on-screen.
Kevin Sussman plays the friendly neighborhood comic book store owner Stuart Bloom. He once played America Ferrera's boyfriend Walter on Ugly Betty.
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