Before Eric Dane played Mark Sloan, he appeared on shows like Charmed and even Saved by the Bell.
Ellen Pompeo? She showed up on Friends before she landed the role as Meredith Grey.
Take a look at all of your favorite Grey's Anatomy cast members to see what they were up to before their roles on Grey's Anatomy (and for some who have left the series already, to see what they did after).
Ellen Pompeo, Then...
We've basically watched Ellen Pompeo grow up on Grey's Anatomy, but before she was Meredith Grey, she had roles on Moonlight Mile, Old School, and Catch Me If You Can. She also appeared on one episode of Friends.
Ellen Pompeo, Now...
Now, Ellen Pompeo plays the darky and twisty Meredith Grey on Grey's Anatomy as the show's lead character. In addition to being an incredible surgeon, she's faced death numerous times, and lost her sister and her husband in unthinkable tragedies.
Patrick Dempsey, Then...
Before we knew him as McDreamy, Patrick Dempsey starred in the films Can't Buy Me Love and Mystic Pizza. Wasn't he adorable? He also starred in the romantic comedy, Made of Honor, which also included Kevin McKidd.
Patrick Dempsey, Now...
Patrick Dempsey won us over as Derek Shepherd, a.k.a. McDreamy from the first time we saw him on Grey's Anatomy Season 1 Episode 1. He and Meredith had an epic love story that tragically ended when Derek was killed in a car accident on Grey's Anatomy Season 11 Episode 21. We're still not over it.
Chandra Wilson, Then...
Before Chandra Wilson landed her role as Miranda Bailey on Grey's Anatomy, she had roles in the films Philadelphia and Lone Star. She also made an appearance on Law and Order.
Chandra Wilson, Now...
Now, she plays Miranda Bailey, formerly nicknamed "The Nazi," and currently acting as the newest chief of surgery and Grey Sloan Memorial Hospital. No one deserves that position more than she does.