But then, an unthinkable tragedy struck them both.
Sometimes, shared grief brings people together to make peace. It's important to remember what really matters.
Not everyone gets along with their exes. For Khloe and Lamar, things are ... more complicated.
Though their divorce was already well underway, when Lamar had his health crisis a few years ago, Khloe dropped everything to be by his side.
That included stalling their divorce process so that Khloe could continue to make decisions for Lamar until he was able to speak for himself.
(Most wives wouldn't exactly slow down a divorce after their husband visits a brothel, but these were ... special circumstances)
Fastforward to 2018, however, and though Lamar himself made a profound recovery, his relationship with Khloe has soured significantly.
As we all know, Khloe Kardashian is pregnant with Tristan Thompson's baby.
Lamar was asked about it, and though he started off politely enough, he decided to make what sounded like an underhanded jab at his ex.
"I'm happy for her," he said at the time.
"She took good care of me. She'll be a good mother, for real. She's a great woman."
However, after acknowledging that he still has Khloe's initials tattooed on his body (from when they got married), he goes out of his way to clarify that he's not pining after her. He just hasn't gotten around to getting the tattoo removed.
"I understand when it's over, it's over. When she was with her second or third NBA ball player, I could see that."
Naturally, that bit of unpleasantness was what got Kim Kardashian to threaten to ruin Lamar Odom if he comes after Khloe again.
On Wednesday morning, Rasual Butler and his wife, Leah LaBelle, died in a one-car wreck in Studio City.
Rasual was a former NBA player.
Leah was a contestant on American Idol in 2004.
It appears that the car, a Range Rover, somehow spun out of control, resulting in the deadly crash.
Many friends of the pair are in mourning over this devastating loss.
RadarOnline reports that they have learned that Khloe and Lamar buried the hatchet while both mourning the loss of their friend.
Rasual had actually appeared on Khloe & Lamar back in the day, when he was dating Malika Haqq.
A source close to Lamar reported that: "Lamar is crushed about Rasual's death, and it was shocking for Khloe, too."
And the tragic situation caused the exes to contact each other.
"Khloe and Lamar talked after they heard about Rasual's death. "
And the source sheds a little insight over how the two of them are feeling.
"She told him that she was so sad about the accident. And he is numb."
Different people respond to sudden horrible news in different ways.
Let's be clear -- this story in no way suggests that Khloe and Lamar are rekindling romantic feelings for each other.
But it's good and healthy for exes like these two to be able to communicate in an honest way. This sadness strikes at them both.