Kathy Griffin took off her clothes for Anderson Cooper. Now she's doing it for David Letterman as well.
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Charlie Sheen appears here on The Late Show with David Letterman... and talks in depth about crack cocaine.
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Michelle Obama stops by the Late Show With David Letterman to discuss her trip to Target and much more. Here's a clip from her March 19, 2012 appearance.
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Anne Hathaway gets grilled by David Letterman on Raffaello Follieri. Quality interview.
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Alec Baldwin describes his Saturday Night Live meeting with Sarah Palin to David Letterman. Funny stuff.
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This interview is an all-timer. Joaquin Phoenix totally spaces out on The Late Show.
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Lauren Conrad makes an appearance on The Late Show with David Letterman on October 27, 2008. So funny.
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CBS' David Letterman and Fox News' Bill O'Reilly go at it on the Late Show, April 2009 edition.
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Lauren Conrad visits The Late Show with David Letterman, who was his usual, hilarious self.
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David Letterman makes fun of Jessica Biel, who brings him up to speed on her dating life. He is apparently quite interested.
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The Late Show host pokes fun at his own wedding with a Top Ten list. You knew it was coming.
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After famously bailing last month, John McCain finally makes it to The Late Show with David Letterman.
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