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Now that McDreamy has departed, the list of original cast members is dwindling. Could Katherine Heigl make a Grey’s Anatomy comeback to ease fans’ despair???

On June 22, during an interview on Entertainment Tonight, Katherine set the record straight.

Nope. Izzy isn’t back.

But there could be a hope that she might make an appearance in the future!!

When asked if she would be interested in returning, Katherine wouldn’t give an answer: “I think that … I don’t know how to answer that, I’m sorry.”

Last year, things weren’t looking so hot for the once A-list actress who is notoriously difficult to work with.  

Reportedly, Heigl was broke and seeking donations to fund a new movie.

And in 2013, she appeared in a Nyquil commercial as a desperate attempt to reboot her collapsed career.

Beggars can’t be choosers. If she is lucky enough to be asked to come back to Grey’s she should jump at the chance.

Heigl said it’s hard to imagine the show after Patrick Dempsey left, but we imagine even McDreamy can’t sink the ABC institution all by himself.

Despite her uncertainty about the show, she is grateful for the experience. Heigl said, “It was just this incredible experience for me."

"It changed the course of my life and career and I couldn’t be more grateful. I just hope it goes for as long as they all want it to.”

As always, you can watch Grey’s Anatomy online to relive the show’s glory years … and many, many more years that came after those.