Over the years, Grey's Anatomy has featured a main character being run over by a bus.
Also: a giant storm, a hospital shooting and a plane crash, among many other large-scale tragedies.
In other words: this long-running ABC drama isn't known for its humor.
But Ellen Pompeo - who may quit acting when the show's run is complete - is perhaps seeking to change that impression, at least based on the following hilarious set photo the actress posted to her WhoSay account.
"Blue is the new black #8daystillgreys #greysanatomy," Pompeo Tweeted in anticipation of the Grey's Anatomy Season 11 opener, which airs on Thursday, September 25 at 8/7c.
Fellow Shonda Rhimes star Kerry Washington retweeted the photo and added as her own caption: