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Demi Lovato is coming to Grey's Anatomy in an upcoming episode of the hit show.

She confirmed the news on her Twitter, and we've learned that she's totally replacing Katherine Heigl! Okay, not really, but she is filming one scene with Alex.

"Demi and Justin Chambers [Alex, husband of Izzie's character] are shooting a scene together tomorrow morning on the set of Grey's Anatomy," reports say.

The Disney star will play a schizophrenia patient in a May episode. "Everyone's super excited around here," Twittered Grey's Anatomy creator Shonda Rhimes.

Demi, who is dating Joe Jonas, herself Twittered that, "Mr. Patrick Dempsey himself wants me to give a shoutout to all you guys! hahahaha so awesome."

She also called the guest spot a "lifelong dream" and wrote "I'm so thrilled to announce that this week I'm shooting Grey's Anatomy!!!!!!!! :D AHHH!!!!"

Pretty much sums it up right there, doesn't it?

Are you excited to see Demi Lovato on Grey's Anatomy?

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Katherine Heigl is leaving Grey’s Anatomy. That you already know, or at least probably suspected. But now the star has officially confirmed the news herself.

I am done,” she said. “We finalized our agreement. Everyone had been working hard to find an amicable way of moving on. It’s sad but it’s what I wanted.”

The actress says that it was family issues, not her burgeoning film career, that prompted her to approach series creator Shonda Rhimes and ask to be let go.

Not sure if we buy that, as she's been angling to be let go for several seasons now and just became a mom late last year, but hey, it definitely sounds better.

“I started a family and it changed everything,” says Heigl, of adopted daughter, Naleigh, with husband Josh Kelley. “It changed my desire to work full-time.”

COMING CLEAN: As much as Katherine Heigl can, anyway.

Although she was scheduled to appear in this season’s final five episodes, that is not happening. The January 21 episode was the last we'll see of her on the hit series that basically made her huge, as she's already been on three-month maternity leave.

“I know I’m disappointing the fans,” she says of her contentious, immature departure. “I just had to make a choice. I hope I made the right one.”

One way to redeem herself to some fans ASAP?

More Katherine Heigl nude scenes. Hot damn!

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Having become the perpetual subject of rumors for her unhappiness on the set, Katherine Heigl is finally leaving Grey's Anatomy after five seasons and change.

Series creator Shonda Rhimes has agreed to release the actress from her deal.

The question is why now, after she's been disgruntled with the series for over two years, but after she unexpectedly came back at the start of the current year?

Because after taking more than half the current season off to make another movie and hang with her adopted daughter, Heigl was scheduled to return March 1.

She did not show.

Katherine Heigl's tenure on Grey's Anatomy has climaxed.

A Heigl source claims that Katherine “was at home and ready to return to work.” Another insider, however, “insists that it’s much more complicated than that.”

Whatever happened, Heigl and ABC mutually decided that the best solution would be to part ways now, rather than waiting for the end of the current season.

Therefore, you've officially seen the last of Dr. Izzie Stevens. Clearly, no love is lost on either side as this ridiculous behind-the-scenes saga finally fades to black.

It's hard to imagine it being managed worse by either side, but it's over now. Will Heigl's career continue to take off? Or is she only hurting it by bolting Grey's?

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The Grey's Anatomy cast just keeps getting bigger.

With today's news that Kim Raver, a.k.a. Dr. Teddy Altman, has been promoted to a full-time star, the ABC medical drama now boasts 14 series regulars.

What does Kim's signing mean for Katherine Heigl's long-term status at Seattle Grace? And what about Cristina (Sandra Oh) and Owen (Kevin McKidd)?

Katherine has already missed numerous episodes this season, both for shooting movies and maternity leave. But she remains under contract ... for now.

Kim Raver is picking up Katherine Heigl's Grey's Anatomy slack.

On the romance front, Kevin (Owen) and Sandra (Cristina) are shooting romantic scenes together for new episodes, so Kim might be the odd girl out.

She'll be a force to be reckoned with on the show in general, though. Raver will appear in all but one of the 12 episodes left in the current sixth season.

This season has been a transitional one at Grey's Anatomy, with Katherine Heigl and Ellen Pompeo missing huge chunks of time and T.R. Knight gone.

At the same time, new characters have been introduced that have helped fill the void and turn the long-running show into more of an ensemble effort.

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Grey's Anatomy hunk Eric Dane and Private Practice leading lady Kate Walsh will be teaming up in the newest crossover of those successful ABC medical dramas.

Here's the crossover situation:

  • On Grey’s Anatomy, Dr. Mark Sloan (Dane) pleads with Addison to come to Seattle and help perform surgery on a patient (guest star Leven Rambin).
  • On Private Practice, complications arise and Mark is forced to take the patient down to L.A. for more surgery, presumably also performed by Addison.

As for Mark's connection to the girl, whether sparks fly between the former lovers, and whether the relationship between Mark and Lexie is at all impacted?

That remains to be seen. But we can only assume it will involve serious surgical and sexual tension, plus a long-winded melodramatic monologue or eight.

Eric Dane and Kate Walsh (right) will cross paths again on Grey's Anatomy and Private Practice. Their medical link? Former All My Children star Leven Rambin (middle).

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If you weren't glued to your TV last night ... good for you.

Social activities are preferable (as is reading Hollywood Gossip online). But if you were in fact plopped on the couch, there was plenty to entertain you.

In addition to the premiere of FlashForward, the guilty pleasure that is The Vampire Diaries and The Office quotes that are always hilarious, there was this:

Grey’s Anatomy kicking off its sixth season with a two-hour episode, picking up where the May's cliffhanger left off and leaving many a tissue box emptied.

Frankly, it was one of the best episodes the long-running has offered us in years - and this is from someone who's seen all 104 of them (sad, but very true).

Here were some of the highlights of the premiere, in which George was laid to rest and the doctors of Seattle Grace struggled to cope in their own ways:

  • Quote of the night, from Chandra Wilson's Miranda Bailey: “I have to stop caring so much. I have to save it for my son. I can’t keep giving it away here.”
  • Quote of the night, runner-up: Mark, after George's death, on the women in his life: "What is it about that guy... was he hung?" Classic Grey's Anatomy.
  • Hottest couple: Owenstina. Sorry, MerDer. Kevin McKidd (Owen) is awesome, and at least Sandra Oh (Cristina) can be shown from the neck down.
  • Horniest couple: Meredith and Derek decided to go at it at every moment (and location). Hot for fans, and a clever move by the producers, as it allowed a pregnant Ellen Pompeo to be on the show, yet rarely visible!
  • Lame, made-for-spoiler moment: Lexie briefly thought it wasn't George who was hit by a bus, disfigured and killed. Cut to commercial. Then we come back and it totally was George! We hate Shonda Rhimes so much.
  • DVR Hall of Fame: The original interns stepped away from the funeral unable to control their despair ... or laughter. They began howling about George's death, Izzie's cancer, and the weddings of Izzie and Meredith.
  • A long road: Izzie was brought back from the brink and is beating cancer. But an uphill battle lies ahead as Alex struggles big-time with her condition.
  • New faces: As usual, characters were introduced that helped tell doctors' stories: Arizona and Lexie were wonderful working with them throughout.
  • Recession special: Seattle Grace is merging with rival Mercy West and there will be layoffs as a result. No one can accuse the show of not being topical.

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Thursday night is shaping up to be quite the TV night.

This isn't a new concept, but with two of the hottest new shows on this evening in addition to the return of a perennial Top 10 drama, it's more true than ever.

At 8 p.m., the CW airs Vampire Diaries, while FlashForward premieres on ABC (and from the looks of the FlashFoward spoilers we've seen so far, it looks great).

Then at 9 p.m., Grey's Anatomy returns for its sixth season. One that its producers and cast say will be unlike any other we've experienced in its long history.

As a teaser for the premiere, the network has leaked the first five minutes of this two-hour Grey's event. Needless to say, we're in for a gripping evening.

Check out the clip below, in which Alex ponders how to tell Izzie about George, Mark and Lexie hear the news, and she makes a surprising declaration ...

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Oft-maligned malcontent Katherine Heigl just got her wish.

The 30-year-old actress will be leaving Grey's Anatomy this fall. At least temporarily. She will be filming the omantic comedy Life as We Know It, reports say.

Grey’s Anatomy has worked around Heigl’s schedule before, but giving her an extended leave is a puzzling move - especially considering her recent behavior.

Katherine Heigl is known as much for disparaging remarks about the show as for her work on it (she won an Outstanding Supporting Actress Emmy in 2007).

The temporary departure of her character, Izzie Stevens, "will be explained on screen," although it’s not yet clear how. Wonder if it ends up being permanent.

A Katherine Heigl Picture

Katherine Heigl: So beautiful. So talented. So obnoxious.

Heigl’s departure, which starts this month, will likely coincide with her co-star Ellen Pompeo’s maternity leave, meaning that Grey’s Anatomy (which just bid farewell to George) will be without Izzie and Meredith at the same time.

Grey’s Anatomy executive producer Shonda Rhimes said that this will be a transitional season for the show, and "eventually, everybody is going to leave."

We just didn't think they'd be shedding cast members so fast.

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Grey's Anatomy fans were shocked when T.R. Knight made the decision to leave the cast of one of TV's biggest shows. They probably shouldn't be.

In an interview with Entertainment Weekly, the 34-year-old reveals what led him to leave Grey's Anatomy, and says it was a long time coming.

The show debuted in 2005, turning Knight into a breakout star who received an Emmy nomination for Outstanding Supporting Actor in 2007.

But it was an incident in late 2006 that changed everything.

Co-star Isaiah Washington referred to Knight as a "f----t" during an on-set argument with Patrick Dempsey, the media caught wind of it, Knight came out of the closet, and Washington was fired from the show the following summer.

That's the short version. T.R. reveals that he does not directly fault executive producer Shonda Rhimes for how she handled the situation, she discouraged him from coming out and a gradual communication breakdown ensued.

T.R. Knight EW Cover

Knight returned to work on Season 4, but struggled a story in which George cheated on wife Callie (Sara Ramirez) with Izzie (Katherine Heigl).

By this past season, the show's fifth, Knight's character George O’Malley all but vanished from the show. Feeling that the character had run its course, and that Rhimes would not give him straight answers, he asked to leave.

"My five-year experience proved I could not trust any answer that was given [about George]," he explains. "With respect, I'm going to leave it at that."

T.R. Knight knows he’s taking a risk walking away from a top 10 show and a $14 million contract: "From an outsider's perspective, I get the [impression that] 'Oh, he’s just a spoiled actor ... he doesn’t know how good he has it.'"

"There are a lot of people who would like to be in my position. But in the end, I need to be fulfilled in my work, and there comes a time when it’s so clear that moving on is the best decision. I have no doubt this was right."

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Following the season finale of Grey's Anatomy, and the gossip that dominated the series all year long, the buzz was that either T.R. Knight or Katherine Heigl, or both, would be leaving the show at the conclusion of the drama's fifth year.

Well, it now appears that T.R.'s George O'Malley will move on into the light after his tragic bus accident, while Katherine's Izzie Stevens will beat brain cancer.

Katherine Heigl Bikini Photo

Knight is leaving the show for good, according to EW. Meanwhile, E! News reports that Heigl "will be back," though neither ABC or the star have commented.

BEST FRIENDS in real life and on TV, T.R. Knight and Katherine Heigl have long been the center of Grey's Anatomy gossip. Looks like one's going and one's coming back.

Season Five's finale left Grey's Anatomy viewers wondering if Izzie, with cancer, would awake after flatlining, while George struggled to survive a bus crash.

The impression you got was that Izzie was ready to return to her life, while George was fine passing on. Looks like this turned out to be the correct conclusion.

Jessica Capshaw, who plays cute lesbian surgeon Arizona, has been signed as a full-time series regular for the upcoming sixth season, premiering in September.