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Five-time Emmy nominee Sandra Oh has announced that she will depart Grey's Anatomy following its 10th season on ABC, ending in May 2014.

The actress said Tuesday, "It's such an interesting thing to play a character for so long and to actually get the sense that she wants to be let go as well."

"Creatively, I really feel like I gave it my all, and I feel ready to let her go."

"[Cristina] wants to be let go, and I am ready to let her go. We have to start the process, story-wise, for the writers to think of why she's going to go."

Oh signed a two-year extension with the series in May 2012, as did co-stars Ellen Pompeo and Patrick Dempsey, whose deals are also up next spring.

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We learned the TVD season premiere title earlier today. Now the Grey's Anatomy Season 10 premiere title has been revealed by ABC sources, as well.

"Seal Our Fate." Sorry Richard?

Grey's Anatomy Lovebirds

The title may not bode well for the character played by original cast member James Pickens, Jr., but it could also mean a number of other things, of course.

The two-hour premiere of the long-running medical drama will focus on the new interns, as well as Meredith and Derek (above) after her brutal birth experience.

Grey's Anatomy Season 10 premieres on Thursday, September 26.

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The world of Grey's Anatomy is about to be rocked again in May's ninth season finale, but not by a mass shooting, plane crash, bus crash or ferry crash. 

What's to come for the doctors? Grey's Anatomy spoilers below ...

Meredith and Derek on Grey's Anatomy

This time it's a weather-related disaster waiting to strike!

A natural disaster, a la Superstorm Sandy, will begin building in the penultimate episode of the ABC medical drama, "Readiness Is All," on May 9.

The May 16 season finale's title: "Perfect Storm."

Sort of sums it up right there, doesn't it?

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Grey's Anatomy star Ellen Pompeo was among the People's Choice Awards winners Wednesday night. For Favorite Dramatic TV Actress, not Favorite Crotch Shot.

She might as well have won the latter, though. When she walked up to accept the honor, she held up her dress, spread her legs and flashed her crotch for all to see.

Grey's Anatomy? More like Pink's Anatomy! Or something. Sorry.

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Grey's Anatomy star Jesse Williams tied the knot with his longtime girlfriend, real estate broker Aryn Drake-Lee, in Los Angeles on Saturday.

The couple, who have been together more than five years, exchanged vows in a romantic, elegant, evening ceremony in front of close family and friends.

"Jesse was beaming with joy throughout the entire ceremony," said a guest at the wedding. "It was the perfect night with lots of smiling, laughing and emotion."

"You could feel the love they have for each other. They're madly in love!"

Jesse Williams Pic

The TV heartthrob first met his bride while he was working as a schoolteacher in New York, before getting his big break in the acting world.

"She's been with me through all different facets of my career," Williams said. "She's stuck with me through thick and thick and thick and thin."

"We know each other in and out."

Congratulations to Jesse and Aryn. For more on the upcoming season of his hit show, check out TV Fanatic's Grey's Anatomy spoilers page!

[Photo: WENN.com]

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The halls of Seattle Grace are about to get a whole lot less steamy. McSteamy, that is, as star Eric Dane has announced his intentions to leave Grey's Anatomy.

“I am extremely grateful to everyone at Grey’s, ABC and Shondaland for the experience and memories I have had over the course of this run,” Dane told TV Line in a statement. “It has been wonderful to work alongside and learn from a creative force such as [creator] Shonda Rhimes.”

Eric Dane as Mark Sloane

Dane will stick around to finish off his character's storyline - Season 8 concluded with Mark Sloane's long-time love, Lexie, dying in a plane crash - as Rhimes said the actor "did not come to this decision lightly," adding:

"We’re a big family here at Grey’s with a long history together and Eric will always remain an important part of our family. I wish him the best and I look forward to watching him as he continues to steam up the big and small screen.”

Grey's Anatomy Season 9 premiere on ABC September 27.

This move should free Dane up with more time to film another naked movie.

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Grey's Anatomy and Broadway star Sara Ramirez is a married woman!

Last week, "On July 4, 2012, after a yearlong engagement, Sara Ramirez and Ryan Debolt were married in an intimate ceremony in New York," he rep says.

"The private event was attended by close family and friends."

Sara and Ryan

Sara Ramirez and Ryan Debolt got engaged in Paris last summer.

As for the fate of Callie's wife Arizona (Jessica Capshaw) on the ABC medical drama, well, she's still lost in the wilderness after the plane crash that killed Lexie.

Something tells THG by the time Grey's Anatomy Season 9 comes around, Arizona, Callie, Mark and Sofia will be a unique, happy family again. Hopefully.

More importantly, congrats to Sara and Ryan on the nuptials!

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Sarah Drew has become a first-time mom.

The Grey’s Anatomy star delivered son Micah Emmanuel Lanfer at 6:21 p.m. Wednesday in Los Angeles. She did not know the gender until that very moment!

“She and her husband, Peter Lanfer, are in love with him!” her rep says of the couple’s new baby boy, who weighed in at 7 lbs., 4 oz and is 19 inches long.

Sarah Drew Pic

Sarah in late November, when she was seven months along.

“I thought it would be a good idea to wait to find out because I'm such a control freak by nature,” Drew explained of their decision to be surprised at the birth.

“I am about to walk into this chapter of my life where I have no control over anything anymore, and I figured I’d ease myself into it by not allowing myself to plan."

"It was hard but in the end it’s good training for me!”

Congratulations to Sarah and her growing family, and expect another new addition to the extended Grey's family this year - Jessica Capshaw is pregnant again!

[Photo: WENN.com]

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Katherine Heigl is not only open to a return to Grey's Anatomy, she admits she's proactively asked if she can reprise her long-gone character, Dr. Izzie Stevens.

Surprising, after leaving the series on a bitter note two years ago after more than one public spat with its producers and ABC. But now she'd welcome a return.

Seriously. The One For the Money star said in a recent interview:

Katie Heigl Pic

"I've told them I want to I don't know... Being a showrunner and being a writer of a TV series like that is so complicated ... how many characters are there now?"

"She's balancing about 40 different storylines, so I don't know if it fits in to their sort of vision for this season or next or however many seasons it goes."

"I really, really, really want to see where [Izzie] is. I just want to know what happened to her and where she went and what she's doing now," she adds.

"My idea is that she actually like figures it out, and finds some success at a different hospital. She was always floundering, always one step behind the eight ball."

"I want to see that girl take some power back."

Would you like to see Heigl on Grey's Anatomy again?

[Photo: WENN.com]

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Grey's Anatomy star Jessica Capshaw is pregnant! Again!

The 35-year-old actress, who gave birth just 14 months ago, announced that she and husband Christopher Gavigan are expecting their third child together.

She wrote on Twitter Tuesday, "It is with profound happiness and sheer delight that @Christopher_Gav and I can say that another sweet Gavigan baby is on the way!"

Jessica Capshaw Photo

Jessica Capshaw has been married to Christopher Gavigan, founder of The Honest Co. and former CEO of Healthy Child Healthy World, since 2004.

She is certainly going to be a busy mom, juggling her hit series with a new baby and 14-month-old daughter Eve and 4-year-old son Luke at home.

The Grey's Anatomy extended family keeps growing, as Eric Dane welcomed his second daughter Georgia on December 28, and Sarah Drew is pregnant as well.

Congratulations to all!

[Photo: WENN.com]

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