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Ellen Pompeo does not share the same reaction as many Grey’s Anatomy fans to the departure of Patrick Dempsey as Dr. Derek Shepherd.

Yes, we’re sure Pompeo is disappointed.

But she isn’t exactly signing a petition to bring McDreamy back.

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Instead, the star (who portrays the ABC drama’s title character, Meredith Grey) is expressing optimism over the potential of where things might now go for Meredith.

“I have always said what keeps me going is the fans. Knowing we move you and inspire you,” Pompeo Tweeted this morning.

While fans mourn the loss of Derek, heading over to watch Grey’s Anatomy online to look for clues that he’s alive (he’s not), Pompeo continued:

"There are so many people out there who have suffered tremendous loss and tragedy. Husbands and wives of soldiers, victims of senseless violence and parents who have lost children. People who get up each day and do what feels like is the impossible.

"So it is for these people and in the spirit of resilance [sic] I am honored And excited to tell the story of how Meredith goes on in the face of what feels like the impossible."

This Thursday, Grey’s Anatomy Season 11 Episode 22 will be a two-hour special that focuses on how Meredith and company say goodbye to Derek.

Will you tune in for it?