It's been a question that's been asked across the Internet for months now, with these two often seen out, about and even grinding at the club.
The rapper has always denied the romance every time it's come up, often referring to Khloe as a "sister" and saying the pair are just friends.
Maybe so, despite rumors to the contrary. But there's another member of this famous family with whom The Game was not always platonic:
Kim Kardashian! He totally tapped that!
The relationship was brief and it happened many years ago, but listen to the artist talk a bit about it in this interview with BBC Radio:
Even if this is true, Game is not the first man Kim gave it up to. Nor is Ray J, or even her first husband Damon Thomas (yes, Kanye will be #3).
See who took Kim Kardashian's v-card in the gallery below, as well as six other celebrities whose first loves may surprise you ... or not so much: