Marcia Gay Harden has decided to end her marriage to Thaddaeus Scheel after 15 years.
"For the sake of the couple's three children, Harden would like to request that the family's privacy be respected at this time," her rep says in a statement.
"No further comments will be made, and thank you for your understanding."
The actress and Scheel have 7-year-old twins and a 13-year-old daughter.
Harden, 52, won the Best Supporting Actress Oscar in 2001 for Pollock. She was also nominated for Best Supporting Actress for Mystic River in 2004.
Most recently, she won a Tony Award in 2009 for God of Carnage.