Two years after the first Stand Up to Cancer special raised $100 million to fight this disease, Emmy, Oscar and Grammy winners gathered in Los Angeles for a live event, televised on all major networks, to do it all again.
"Cancer doesn't care how may Oscars you've won, or how many tough guys you've played," said Michael Douglas, who is battling stage-4 throat cancer, one of several past and current cancer patients who played a role on the special, including: Michael C. Hall, Christina Applegate, Maura Tierney, Lance Armstrong, Kareem Abdul Jabar, Fran Drescher, Kylie Minogue and Survivor's Ethan Zohn.
Watch a couple highlights from Stand Up to Cancer below.
At one point, Stevie Wonder paid tribute to his first wife, who died of breast cancer, before joining Natasha Bedingfield, Leona Lewis, the Edge, Dave Stewart, Martina McBride and Aaron Neville for a rendition of "Unchained Melody."
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** Donations can be made to standup2cancer.org or by calling 1-888-90-STAND.