The funnywoman opened the show with a hilarious and potty-mouthed monologue in which she accused Spider-Man 3 of being racist (really) and told Jack Nicholson, "You have literally been in every single one of my favorite actresses!"
But the most ridiculed celebrity of the evening was Paris Hilton, who took hits from Silverman as well as Dane Cook, who cracked, "Paris Hilton was so offended by Sarah Silverman's opening remarks that she checked herself into jail early."
Amy Winehouse gave the best performance of the evening when she rocked the house with her sultry tune "Rehab."
The Best Close Call of the night was Jessica Biel presenting the Best Kiss award (along with Kevin James and Adam Sandler), for which none other than Cameron Diaz was a nominee for her smooch with Jude Law in The Holiday.
Luckily, Talladega Nights' Will Ferrell and Sacha Baron Cohen took home the golden popcorn in that category, avoiding a potentially awkward run-in.
Diaz, meanwhile, had plenty of love for Shrek the Third costar Mike Myers who she presented with the MTV Generational Award.
After a gushing speech in which she said that Myers made her laugh harder than anyone she'd ever met, she coquettishly asked the audience, "Should I shag him now? Or should I shag him later?"
Justin Timberlake, Diaz's ex and Biel's current love, wisely avoided the evening, opting not to attend the awards. If you didn't catch the show either, see a list of the winners below:
BEST MOVIE: Pirates of the Caribbean: Dead Man's Chest
BEST VILLAIN: Jack Nicholson, The Departed
BEST PERFORMANCE: Johnny Depp, Pirates of the Caribbean: Dead Man's Chest
BREAKTHROUGH PERFORMANCE: Jaden Smith, The Pursuit of Happyness
BEST COMEDIC PERFORMANCE: Sacha Baron Cohen, Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan
BEST KISS: Will Ferrell and Sacha Baron Cohen, Talladega Nights: The Ballad of Ricky Bobby
BEST FIGHT: Gerard Butler vs. "The Uber Immortal," 300
BEST SUMMER MOVIE YOU HAVEN'T SEEN YET: Transformers
MTV GENERATIONAL AWARD: Mike Myers