Jennifer Aniston, Vince Vaughn and Others are The People's Choices

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Whew. This could've been awkward.

Both Jennifer Aniston and Vince Vaughn won People's Choice Awards for their breakup â€" that is, their movie The Break-Up â€" last night. Fortunately, good humor and class ruled the evening.

Jennifer Aniston in Hollywood

Aniston was named favorite female star, while Vaughn was picked by the public as favorite leading man.

"You all have supported me since the days of Friends," Aniston told the audience, "just through all of it â€" good work, bad work and the ugly. I just thank you."

Aniston also poked a little fun at Britney Spears, quipping about the short skirt she was wearing: "Man, I tell you, it's a lucky thing we do wear underwear, huh?"

Among other winners, Johnny Depp, who was filming in London and unable to attend the ceremony, accepted his favorite male movie star and male action star for Pirates of the Caribbean: Dead Man's Chest via satellite.

He and costar Keira Knightley were also selected favorite onscreen match-up.

Grey's Anatomy, meanwhile, was a double winner: favorite TV drama and Patrick Dempsey, favorite male TV star.

"Thank you for a second chance!" Dempsey told the crowd. "I'm very fortunate to be part of a great ensemble." To the show's creator, Shonda Rhimes, he said: "Thank you for creating Dr. McDreamy, it's changed my life."

And Desperate Housewives's Eva Longoria, who was named favorite female TV star, told the crowd: "If it wasn't for the people, I'd never win an award."

Justin Timberlake's "SexyBack" was named favorite R&B song, while Carrie Underwood and Kenny Chesney were cited as favorite singers.

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Well, the whole Aniston also poked a little fun at Britney Spears, quipping about the short skirt she was wearing: "Man, I tell you, it's a lucky thing we do wear underwear, huh?" well that's crap! Someone grabbed the back of her dress as she was walking up to get her award! I could do better reporting from my couch!!!

Jennifer Aniston Quotes

I actually feel I've been unbelievably lucky in love. I don't feel like I'm supposed to be any further along or somewhere that I'm not. I'm right where I'm supposed to be.

Jennifer Aniston

You just have to love your life. I have my health, I have my friends, I have my loved ones. I'm extremely lucky.

Jennifer Aniston